The battle for bragging rights in Ohio is renewed Friday when the Cleveland Guardians (25-18) travel to Cincinnati to take on the Reds (21-24).
Tanner Bibee is slated to take the mound for Cleveland against Brady Singer for Cincinnati.
The Reds were 7-1 winners Thursday against the White Sox. Elly De La Cruz and Will Benson combined to go 4-7 with two home runs and four RBIs to pace the attack.
The Guardians were off Thursday. They took two of three earlier this week against the Brewers. The two wins were each shutouts. Cleveland now has six shutouts on the season which puts them tied atop the American League in that category with the Kansas City Royals.
Lets dive into the matchup and find a sweat or two.
We’ve got all the info and analysis you need to know ahead of the game, including the latest info on the how to catch tipoff, odds, recent team performance, player stats, and of course, our predictions, picks & best bets for the game from our modeling tools and staff of experts.
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Game details & how to watch Guardians at Reds
- Date: Friday, May 16, 2025
- Time: 6:40PM EST
- Site: Great American Ball Park
- City: Cincinnati, OH
- Network/Streaming: CLEG, FDSNOH
Never miss a second of the action and stay up-to-date with all the latest team stats and player news. Check out our day-by-day MLB schedule page, along with detailed matchup pages that update live in-game with every out.
Odds for the Guardians at the Reds
The latest odds as of Thursday:
- Moneyline: Guardians (-116), Reds (-102)
- Spread: Guardians -1.5
- Total: 9.0 runs
Probable starting pitchers for Guardians at Reds
- Pitching matchup for May 16, 2025: Tanner Bibee vs. Brady Singer
- Guardians: Tanner Bibee (3-3, 3.80 ERA)
Last outing: 5/10 vs. Philadelphia – 7IP, 1ER, 5H, 0BB, 3Ks - Reds: Brady Singer (4-2, 4.97 ERA)
Last outing: 5/10 at Houston – 2.1IP, 7ER, 9H, 1BB, 1K
- Guardians: Tanner Bibee (3-3, 3.80 ERA)
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Top betting trends & insights to know ahead of Guardians at Reds
- The Guardians have won 4 of their last 5 road games against teams with losing records
- 8 of the Reds’ last 9 games with the Guardians have stayed under the Total
- When the Guardians have had a rest advantage, they have covered the Run Line in 8 of their last 10 games
- Elly De La Cruz was 3-8 (.375) in Chicago’s 1-game series against the White Sox
- Steven Kwan is 5-16 (.313) over his last 4 games
If you’re looking for more key trends and stats around the spread, moneyline and total for every single game on the schedule today, check out our MLB Top Trends tool on NBC Sports!
Expert picks & predictions for Friday’s game between the Guardians and the Reds
Rotoworld Best Bet
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Our model calculates projections around each moneyline, spread and over/under bet for every game on the MLB calendar based on data points like past performance, player matchups, ballpark information and weather forecasts.
Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.
Here are the best bets our model is projecting for Friday’s game between the Guardians and the Reds:
- Moneyline: NBC Sports Bet is recommending a play on the Cleveland Guardians on the Moneyline.
- Spread: NBC Sports Bet is leaning towards a play ATS on the Cincinnati Reds at +1.5.
- Total: NBC Sports Bet is recommending a play on the over on the Game Total of 9.0.
Want even more MLB best bets and predictions from our expert staff & tools? Check out the Expert MLB Predictions page from NBC
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- Jay Croucher (@croucherJD)
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